【期刊論文】探索功能性食品應用於缺血性中風失語症的效果

背景與目的：

本研究旨在探索功能性食品應用於缺血性中風失語症的效果。

當中風相關的神經功能障礙導致身體依賴以及無法自我照顧的時間持續超過6 個 月，完全恢復幾乎是不可能的，病人往往需要長期照顧。這裡提到的功能性食品，EASE123 和 BioBalance＃6，包括許多以植物和海產為基礎的營養補充劑，可以證明對此類患者有益。

方法與研究設計：

此開放標記的研究納入10 例確診為陳舊性缺血性中風和失語症持續超過6 個月的患者。每個病人在 10:30 AM 及睡前90 分鐘分別服用6 粒 EASE123，於2:30 PM 服用3 粒 BioBalance＃6。

12 週的治療期後是一個為期4 週的停藥觀察期。分別在第4、 8、12 和16 週，使用簡明中國失語症測試（CCAT）分數和子項目分數評估功 能改善的效果。

結果：

研究發現平均總 CCAT (簡明失語症測驗)分數、和圖像配對能力，在第4、 8、12 和16 周有顯著改善（p<0.05）。

簡單應答分數在第8 和12 周有顯著改善 （p<0.05）。

聽覺理解在第4 和12 週（p<0.05），及閱讀理解在第12 周有顯 著改善（p<0.05）。

複誦句子在第8、12 和16 周顯著改善（p<0.05），且自發書寫在第4、12 和16 周有顯著改善（p<0.05）。

結論：

圖物配對、複誦句子和 平均總CCAT 分數於整個研究過程中皆有顯著改善。因此，缺血性中風6 個月 後，給予EASE123 和BioBalance＃6 營養補充劑可以改善缺血性中風失語症。


原文網址：https://www.ncbi.nlm.nih.gov/pubmed/27222409/

Open-labelled observations of language dysfunction in old ischemic stroke patients with aphasia when given plant and marine-based nutrient supplements for 12 weeks.

Author: Lin GY, Chan HY, Cheng CA, Lin LP, Peng GS, Hsiao PM, Lin CC, Lin CC, Lee JT.

Abstract

BACKGROUND AND OBJECTIVES:
This study aimed to explore the effect of functional foods on aphasia related to a previous ischemic stroke. When stroke-related neurological deficits result in physical dependency and poor selfcare that persists longer than 6 months, full recovery is almost impossible and the patient often requires long-term care. The functional foods, EASE123 and BioBalance#6, include numerous plant and marine-based nutrient supplements that could prove beneficial for such patients.

METHODS AND STUDY DESIGN:
This open-labelled study included 10 patients diagnosed with prior ischemic stroke and aphasia lasting longer than 6 months. Each patient was administered 6 tablets of EASE123 at 10:30 AM and at 90 minutes before sleeping, and 3 tablets of BioBalance# 6 at 2:30 PM. After a treatment period of 12 weeks, the patients were followed during a 4-week withdrawal period. Functional improvement was assessed by scores and subscores on the Concise Chinese Aphasia Test (CCAT) at weeks 4, 8, 12, and 16.

RESULTS:
Average total CCAT scores and matching ability improved significantly at weeks 4, 8, 12, and 16 (p<0.05). Simple response scores improved significantly at weeks 8 and 12 (p<0.05). Auditory comprehension improved significantly at weeks 4 and 12 (p<0.05), and reading comprehension, at week 12 (p<0.05). Repetition ability improved significantly at weeks 8, 12, and 16 (p<0.05), and spontaneous writing, at weeks 4, 12, and 16 (p<0.05).

CONCLUSIONS:
Matching, repetition, and average total CCAT scores improved over the course of the study. Therefore, 6 months after ischemic stroke, EASE123 and BioBalance# 6 administration may improve stroke-related aphasia.